● Crosstalk between obesity-induced inflammation and energy metabolism 

● Obesity-mediated adipose tissue dysfunction and NAFLD pathogenesis

● Regulatory mechanism of cell-to-cell interactions in obesity-mediated NAFLD

● Roles and regulatory mechanism of Tank-binding kinase 1 (TBK1) in NAFLD

● Regulatory mechanisms for ACSL1 localization for hepatic lipid homeostasis 

(* the first author)

1. Huh JY*, Reilly S, Abu M, Murphy A, Mahata S, Zhang J, Cho Y, Seo JB, Hung C, Green C, Metallo C, Saltiel A. TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Cell Metab. 2020, 1;32(6):1012-1027

2. Huh JY* and Kim JB. TIM4 + adipose tissue-resident macrophages: new modulators of adiposity. Nat. Rev. Endocrinol. 2021 Nov;17(11):645-646

3. Huh JY* and Saltiel A. Roles of IκB Kinases and TANK-binding Kinase 1 in Hepatic Lipid Metabolism and Non-alcoholic Fatty Liver Disease. Exp. Mol. Med. 2021 Nov;53(11):1697-1705

4. Huh JY*, Park YJ, Kim JB. Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity. Adipocyte. 2018;7(2):129-136.

5. Huh JY*, Park J, Kim JI, Park YJ, Lee YK, Kim JB. Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity. Diabetes. 2017 Apr;66(4):835-847.

6. Huh JY*, Park YJ, Ham M, Kim JB. Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol. Cells. 2014 May;37(5):365-71.

7. Huh JY*, Kim JI, Park YJ, Hwang IJ, Lee YS, Sohn JH, Lee SK, Alfadda AA, Kim SS, Choi SH, Lee DS, Park SH, Seong RH, Choi CS, Kim JB. A novel function of adipocytes in lipid antigen presentation to iNKT cells. _{Mol. Cell. Biol.} 2013 Jan;33(2):328-39. 

8. Lee YS*, Li P*, Huh JY*, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB. Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes. 2011 Oct;60(10):2474-83.