학력 및 경력

2003.08   서울대학교 미생물학 전공 학사
2009.12   Dept. of Pathology, Vanderbilt University. Ph.D.
2010.08   Dept. of Pathology, Vanderbilt University. Postdoctoral research fellow.
2016.10   Dept. of Experimental Radiation Oncology, UT MD Anderson Cancer Center. Postdoctoral research fellow.
2019.02   Dept. of Experimental Radiation Oncology, UT MD Anderson Cancer Center. Research Investigator.
 

개설강의

세포학

분자세포종양학

생체신호체계론​
 

연구분야

암은 한국인의 사망 원인 1위의 질병으로, 주로 세포의 유전적인 돌연변이에 의해 발생하는 것으로 알려져 있다. 본 연구실에서는 PTM (post-translational modification)을 조절하는 enzyme 이나 microRNA, long non-coding RNA와 같은 non-coding RNA 가 어떻게 암의 발달과 전이를 조절하는지를 규명하고자 한다 . 이를 통하여, 암의 효과적인 치료를 위한 새로운 표적을 찾고자 하는데, 세포생물학, 분자생물학 그리고 마우스 유전학 등의 연구 방법을 활용하고 있다. 

연구업적

Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 50(12):1705-1715. (Dec, 2018)

Kim J, Alavi Naini F, Sun Y, Ma L. Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin. Am J Cancer Res. 8(9):1823-1836. (Sep, 2018)

Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton BN, Chang L, Liu N, Zeng L, Wang W, Wang Y, Zhang P, Hu X, Su X, Liang H, Sun Y, Ma L. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 11;9(1):2269. (Jun, 2018)

Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep. 17;23(3):823-837. (Apr, 2018)

Kim J, Yao F, Xiao Z, Sun Y, Ma L. MicroRNAs and metastasis: small RNAs play big roles. Cancer Metastasis Rev. 37(1):5-15. (Mar, 2018)

Zhou Z, Zhang P, Hu X, Kim J, Yao F, Xiao Z, Zeng L, Chang L, Sun Y, Ma L. USP51 promotes deubiquitination and stabilization of ZEB1. Am J Cancer Res. 7(10):2020-2031. (Oct, 2017)

Kim J, Siverly AN, Chen D, Wang M, Yuan Y, Wang Y, Lee H, Zhang J, Muller WJ, Liang H, Gan B, Yang X, Sun Y, You MJ, Ma L. Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res. 76(21):6424-6435. (Nov, 2016)

Lee H, Dai F, Zhuang L, Xiao ZD, Kim J, Zhang Y, Ma L, You MJ, Wang Z, Gan B. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget. 7(15):19134-46. (Apr, 2016)

Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, Wang Y, Chou CK, Hsu JM, Lai YJ, LaBaff AM, Ding Q, Ko HW, Tsai FJ, Tsai CH, Hortobagyi GN, Hung MC. AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res. 76(6):1451-62. (Mar, 2016)

Kim J, Roh M, Doubinskaia I, Algarroba GN, Eltoum IE, Abdulkadir SA. A mouse model of heterogeneous, c-MYC-initiated prostate cancer with loss of Pten and p53. Oncogene. 19;31(3):322-32. (Jan, 2012)

Kim J, Roh M, Abdulkadir SA. Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity. BMC Cancer. 1;10:248. (Jun, 2010)

Wang J, Kim J, Roh M, Franco OE, Hayward SW, Wills ML, Abdulkadir SA. Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma. Oncogene. 29;29(17):2477-87. (Apr, 2010)

Kim J, Eltoum IE, Roh M, Wang J, Abdulkadir SA. Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer. PLoS Genet. 5(7):e1000542. (Jul, 2009)

Roh M, Kim J, Song C, Wills M, Abdulkadir SA. Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues. Genesis. 44(10):447-53. (Oct, 2006)

Roh M, Song C, Kim J, Abdulkadir SA. Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1. J Biol Chem. 280(49):40568-77. (Dec, 2005)