◆ 학력 및 경력

<학력>

2007. 03. – 2012. 02. Ph.D. in Agricultural Biotechnology, Seoul National University (Research adviser: Sang Ho Choi, Ph.D.)

2003. 03. - 2007. 02. B.S. in Food Science and Biotechnology, College of Agriculture and Life Sciences, Seoul National University

<경력>

2018.03. – Present. Principal investigator, Molecular Systems Microbiology Lab.

2025.09. - Present. Associate Professor, Department of Life Science, College of Natural Science, Sogang University

2018.03. – 2025.08. Assistant & Associate Professor, Department of Food Science & Biotechnology, College of Engineering, Ewha Womans University

2016.04. - 2018.02. Post-doctoral Fellow, Infection and Immunity Research Lab, Korea Research Institute of Bioscience & Biotechnology (KRIBB)

                         (Research adviser: Myung Hee Kim, Ph.D.)

2016.03. Researcher, Center for Food Safety and Toxicology, Seoul National University

2012.10. - 2016.02. Research Associate, Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL

                         (Research adviser: Karla J. F. Satchell, Ph.D.)

2012.03. - 2012.08. Post-doctoral Fellow, Department of Agricultural Biotechnology, Seoul National University. (Research adviser: Sang Ho Choi, Ph.D.)

2009.10. - 2010.09. Pre-doctoral Scholar, Department of Microbiology, University of Washington, Seattle, WA (Research Adviser: Dr. Everett Peter Greenberg, Ph.D.)

◆ 학회활동 및 수상

- International Union of Microbiological Societies (IUMS): International Cooperation Committee (2020)

- The Microbiological Society of Korea (MSK, 한국미생물학회): 평의원 (2020~현재), 공익위원 (2019, 2020, 2026), 재무위원 (2021, 2022), 생리/생화학분과 위원 (2023~현재)

- The Korean Society for Microbiology and Biotechnology (KMB, 한국미생물생명공학회): 평의원 (2020~현재), 소식지편집간사 (2020, 2021), 홍보간사 (2022), 학술간사 (2023, 2026), MBL 편집간사 (2024~현재), 의과학분과 학술간사 (2019~현재)

- Journal of Microbiology and Biotechnology, Editor (2025~현재)

- Microbiology and Biotechnology Letters, Deputy Editor (2024~현재)

- Food Science and Biotechnology, Editor (2024~현재)

- Ministry of Science and ICT: Expert in Technology Level Evaluation (2018~2023)

- Ministry of Food and Drug Safety: Evaluation committee member for GMO & novel food items (2022~현재), 새로운 식품원료 전문가 자문단 (2024~현재)

- 학술장려상, 한국미생물·생명공학회 (2023)

- 우수편집자상, Journal of Microbiology and Biotechnology, 한국미생물·생명공학회 (2025)

- 우수편집자상, Microbiology and Biotechnology Letters, 한국미생물·생명공학회 (2021 & 2024)

- Travel Grant, ASM conference on Vibrio 2017. American Society for Microbiology (2017)

◆ 개설강의 

- 학부 교양: 생명과 환경 (Life and Environment)

- 학부 전공: 미생물학 (Microbiology), etc

- 대학원: 분자미생물병리학 (Microbial Molecular Pathogenesis), etc

◆ 연구분야 

For more details, please visit the website of the Molecular Systems Microbiology Lab. (https://sites.google.com/view/mfmt/)

 Our lab investigates molecular mechanisms of how microbes interact with humans and other microbes (including bacteriophages) to understand their life and physiological characteristics. We also develop innovative strategies for combating harmful (foodborne) pathogens and harnessing beneficial microbes. Specifically, we study microbial attack mechanisms (e.g., protein toxins and virulence factors) and host defense mechanisms (e.g., immune responses and bacteriophage resistance) using advanced approaches in molecular microbiology, microbial genetics, and cellular/biochemical research. By integrating engineering biology and systems biology, we also aim to leverage these microbial traits for beneficial applications.

1. HOST-MICROBE INTERACTION 1: VIRULENCE FACTOR [supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT (Sep. 2023 ~ )]

1.1. MARTX toxin

1.2. CsgD

2. HOST-MICROBE INTERACTION 2: MICROBIOTA/MICROBIOME [supported by Basic Research Laboratory Program (Jun. 2023 ~ Aug. 2025) and Pioneering Research Program (Sep. 2025 ~ ) through the National Research Foundation of Korea funded by the Ministry of Science and ICT]

2.1. Bitter Taste and Oral Microbiome

2.2. Microbial Metabolite-Taste Receptor Interactions

3. MICROBE-MICROBE INTERACTION: BACTERIOPHAGE

3.1. Bacteriophage

3.2. Endolysin

◆ 연구업적(selected list; underline, MSM lab.; #, co-corresponding author; *, co-first authors)

MARTX toxin

1. J. Lee, Y. Kim, and B.S. Kim. 2025. Non-Repeat Segment 1 in Vibrio vulnificus MARTX toxin, which binds to biantennary N-glycans, is essential for host cell blebbing but dispensable for effector translocation. Microbiol. Res. 295:128108 [Link]

2. S. Choi, Y. Lee, S. Park, S.Y. Jang, D.W. Oh, S.-M. Kim, T.-H. Kim, J. Park, C. Cho, B.S. Kim, G. S. Lee, D. Lee, E.-H. Kim, H.K. Cheong, J. H. Moon, J.-J. Song, and M.H. Kim. 2024. Dissemination of pathogenic bacteria is reinforced by a MARTX toxin effector duet. Nat. Commun. 15: 6218. [Link] [Featured in Magazine]

3. H. Y. Chung, Y. Bian, K.-M. Lim, B. S. Kim, and S. H. Choi. 2022. MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis. Nat. Commun. 13: 4846. [Link]

4. C. Cho, S. Choi, M. H. Kim, and B. S. Kim. 2022. Vibrio vulnificus PlpA facilitates necrotic host cell death induced by the pore forming MARTX toxin. J. Microbiol. 60(2):224-233. [Link] [PDF]

5. S. Choi, B. S. Kim, J. Hwang#, and M. H. Kim#. 2021. Reduced virulence of the MARTX toxin increases the persistence of outbreak-associated Vibrio vulnificus in host reservoirs. J. Biol. Chem. 296:100777. [Link]

6. Byoung Sik Kim. 2020. Spatiotemporal regulation of Vibrio exotoxins by HlyU and other transcriptional regulators. Toxins. 12(9):E544. [Link]

7. B. S. Kim*#, J. -H. Kim*, S. Choi, S. Park, E. -Y. Lee, S. Koh, C. -M. Ryu, S. -Y. Kim#, and M. H. Kim#. 2020. MARTX Toxin-Stimulated Interplay between Human Cells and Vibrio vulnificus. mSphere. 5, e00659-00620. [Link]

8. Z. -W. Lee, S. -H. Hwang, G. Choi, K. K. Jang, T. H. Lee, K. M. Chung, B. S. Kim, and S. H. Choi. 2020. A MARTX toxin rtxA gene is controlled by host environmental signals through a CRP-coordinated regulatory network in Vibrio vulnificus. mBio. 11(4):e00723-20. [Link]

9. Y. Lee*, B. S. Kim*, S. Choi, E.-Y. Lee, S. Park, J. Hwang, Y. Kwon, J. Hyun, C. Lee, J. F. Kim, S. H. Eom, and M. H. Kim. 2019. Makes caterpillars floppy-like effector containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity. Proc. Natl. Acad. Sci. U.S.A. 116(36):18031-18040. [Link] [Highlighted in YTN News]

10. Z. -W. Lee, B. S. Kim, K. K. Jang, Y. -J. Bang, S. Kim, N. -C. Ha, Y. H. Jung, H. J. Lee, H. J. Han, J. -S. Kim, J. Kim, P. K. Sahu, L. S. Jeong, M. H. Kim, and S. H. Choi. 2019. Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species. Sci. Rep. 9: 4346. [Link]

11. Byoung Sik Kim. 2018. The modes of action of MARTX Toxin effector domains. Toxins. 10(12):507. [Link]

12. S. Y. Jang*, J. Hwang*#, B. S. Kim, E.-Y. Lee, B. -H. Oh#, and M. H. Kim#. 2018. Structural basis of inactivation of Ras and Rap1 small GTPases by Ras/Rap1-specific endopeptidase from the sepsis-causing pathogen Vibrio vulnificus. J. Biol. Chem. 293:18110-18122. [Link]

13. K. K. Jang, Z. –W. Lee, B. Kim, Y. H. Jung, H. J. Han, M. H. Kim, B. S. Kim#, and S. H. Choi#. 2017. Identification and characterization of Vibrio vulnificus plpA encoding a phospholipase A2 essential for pathogenesis. J. Biol. Chem. 292:17129-17143. [Link]

14. B. S. Kim, H. E. Gavin, and K. J. F. Satchell. 2017. Variable virulence of biotype 3 Vibrio vulnificus due to MARTX toxin effector domain composition. mSphere. 2:e00272-17. [Link]

15. B. S. Kim and K. J. F. Satchell. 2016. MARTX effector cross kingdom activation by Golgi-associated ADP-ribosylation factors. Cell. Microbiol. 18:1078-1093. [Link]

16. B. S. Kim, H. E. Gavin, and K. J. F. Satchell. 2015. Distinct roles of the repeat-containing regions and effector domains of the Vibrio vulnificus multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin. mBio. 6(2):e00324-15. [Link]

17. B. C. Lee, J. H. Lee, M. W. Kim, B. S. Kim, M. H. Oh, K. -S. Kim, T. S. Kim, and S. H. Choi. 2008. Vibrio vulnificus rtxE is important for virulence, and its expression is induced by exposure to host cells. Infect. Immun. 76:1509-1517. [Link]

18. J. H. Lee, M. W. Kim, B. S. Kim, S. M. Kim, B. C. Lee, T. S. Kim, and S. H. Choi. 2007. Identification and characterization of the Vibrio vulnificus rtxA essential for cytotoxicity in vitro and virulence in mice. J. Microbiol. 45: 146-152. [Link]

Bacteriophage

1. H. Seol, B.S. Kim#, and M. Kim#. 2024. Control of Bacillus cereus in rice cake and food contact surfaces with novel Becedseptimavirus genus phage BCC348 and its partial SPOR domain-containing endolysin LysBCC348. LWT. 231:117034. [Link]

2. M. Oh, A. Cevallos-Urena, and B.S. Kim. 2024. Bacteriophages PECP14, PECP20, and their endolysins as effective biocontrol agents for Escherichia coli O157:H7 and other foodborne pathogens. Int&l. J. Food Microbiol. 409:110460. [Link]

3. J. H. Lee, M. Oh, and B. S. Kim. 2023. Phage biocontrol of zoonotic food-borne pathogen Vibrio parahaemolyticus for seafood safety. Food Control. 144:109334. [Link]

4. H. J. You*, J. H. Lee*, M. Oh, S. Y. Hong, D. Kim, J. Noh, M. Kim#, and B. S. Kim#. 2021. Tackling Vibrio parahaemolyticus in ready-to-eat raw fish flesh slices using lytic phage VPT02 isolated from market oyster. Food Res. Int. 150:110779. [Link]

Transcriptional Regulation -Systems approach

1. B. Seok, M.-S. Kim, and B.S. Kim. 2024. Genome-wide analysis of quorum sensing regulon in marine fish pathogen Vibrio scophthalmi. Sci. Rep. 14:27740. [Link]

2. D. Bae*, S.H. Lee*, J.H. Park, S.Y. Son, Y. Lin, J.H. Lee, B.R. Jang, K.H. Lee, Y.H. Lee, H.S. Lee, S.G. Kang, B.S. Kim, and S.S. Cha. 2023. An archaeal transcription factor EnfR with a novel &eighth note& fold controls hydrogen production of a hyperthermophilic archaeon Thermococcus onnurineus NA1. Nucleic Acids Res. 51(18):10026-10040. [Link]

3. S. Y. Hong and B. S. Kim 2023. Screening of anti-adhesion agents for pathogenic Escherichia coli O157:H7 by targeting the GrlA activator. J. Microbiol. Biotechnol. 33(3):1-10. [Link]

4. H. Im, S.-H. Hwang, B. S. Kim, and S. H. Choi. 2021. Pathogenic potential assessment of the Shiga toxin-producing Escherichia coli by a source attribution-considered machine learning model. Proc. Natl. Acad. Sci. U.S.A. 118(20):e2018877118. [Link]

5. B. S. Kim*, S. Y. Jang*, Y. -J. Bang, J. Hwang, Y. Koo, K. K. Jang, D. Lim, M. H. Kim, and S. H. Choi. 2018. QStatin, a selective inhibitor of quorum sensing in Vibrio species. mBio. 9(1):e02262-17. [Link]

6. J. Hwang*, B. S. Kim*, S. Y. Jang, J. G. Lim, D. -J. You, H. S. Jung, T, -K. Oh, J. –O. Lee, S. H. Choi, and M. H. Kim. 2013. Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Proc. Natl. Acad. Sci. U.S.A. 110:E2829-2837. [Link] [Highlighted in YTN News]

7. S. Chugani, B. S. Kim, S. Phattarasukol, M. J. Brittnacher, S. H. Choi, C. S. Harwood, and E. P. Greenberg. 2012. Strain-dependent diversity in the Pseudomonas aeruginosa quorum-sensing regulon. Proc. Natl. Acad. Sci. U.S.A. 109:E2823-E2831. [Link]

8. B. S. Kim, J. Hwang, M. H. Kim, and S. H. Choi. 2011. Cooperative regulation of the Vibrio vulnificus nan gene cluster by NanR protein, cAMP receptor protein, and N-acetylmannosamine-6-phosphate. J. Biol. Chem. 286:40889-40899. [Link]

9. M. S. Lim, J. A. Kim, J. G. Lim, B. S. Kim, K. C. Jeong, K. H. Lee, and S. H. Choi. 2011. Identification and characterization of a novel serine protease, VvpS, that contains two functional domains and is essential for autolysis of Vibrio vulnificus. J. Bacteriol. 193:3722-3732. [Link]

10. Y. Kim*, B. S. Kim*, Y. J. Park, W. -C. Choi, J. Hwang, B. S. Kang, T. -K. Oh, S. H. Choi, and M. H. Kim. 2010. Crystal structure of SmcR, a quorum-sensing master regulator of Vibrio vulnificus, provides insight into its regulation of transcription. J. Biol. Chem. 285:14020-14030. [Link]

11. H. G. Jeong, M. H. Oh, B. S. Kim, M. Y. Lee, H. J. Han, and S. H. Choi. 2009. The capability of catabolic utilization of N-acetylneuraminic acid, a sialic acid, is essential for Vibrio vulnificus pathogenesis. Infect. Immun.77:3209-3217. [Link]