학력 및 경력

<학력>

2016 서울대학교 생명과학부, 박사

2009 서울대학교 동물생명공학, 학사

<경력>

2026-present 서강대학교 조교수

2026-present 서울대학교 겸임조교수

2018-2026  서울대학교 IBS RNA 연구단 연수, 선임, 책임연구원

2016-2018  서울대학교 자연과학대학 연수연구원 

연구분야

RNA는 단순한 유전정보의 전달자가 아니라, 세포 내 다양한 생명현상을 정교하게 조절하는 핵심 분자로 알려져 있다. 바이러스는 자신의 증식을 위해 숙주 세포가 가진 RNA 조절 기작을 정교하게 활용(hijacking)하기 때문에, 바이러스 RNA를 연구하는 것은 바이러스 자체를 이해하는 것을 넘어, 아직 밝혀지지 않은 숙주 세포의 RNA 조절 원리를 규명할 수 있는 효과적인 접근법이 된다. 본 연구실에서는 바이러스가 숙주 세포 내에서 RNA를 어떻게 조절하고 활용하는지를 분자 수준에서 규명하고, 이 과정에서 새롭게 발견되는 RNA 조절 메커니즘을 항바이러스 치료제 개발 및 RNA 기반 신약 개발에 응용하고자 한다. 이를 위해 분자생물학, 생화학, 생물정보학 등의 연구 방법을 활용하고 있다.

연구업적

•    Jung S-J*, Seo JJ*, Lee S*, Hyun S-I, Lee J-e, Lee S, Lee Y, Chang H, Lee H, Kim J-H, Kim VN (2025) RNA stability enhancers for durable, based-modified mRNA therapeutics. Nature Biotechnology. (*co-first authors)

•    Kim H-J, Cho S-Y, Jung S-J, Cho Y-J, Roe J-H, Kim K-d (2024) Non-Mitochondrial Aconitase-2 mediates the transcription of nuclear-encoded electron transport chain genes in fission yeast. Journal of Microbiology.

•    Seo JJ*, Jung S-J*, Yang J, Choi D-E, Kim VN (2023) Functional viromic screens uncover regulatory RNA elements. Cell. 186(15):3291–3306 (*co-first authors)

•    Cho S-Y, Jung S-J, Kim K-d, Roe J-H (2021) Non-mitochondrial aconitase regulates the expression of iron-uptake genes by controlling the RNA turnover process in fission yeast. Journal of Microbiology. 59(12):1075–1082

•    Kim D*, Lee Y-s*, Jung S-J*, Yeo J*, Seo JJ, Lee Y-Y, Lim J, Chang H, Song J, Yang J, Kim J-s, Jung G, Ahn K, Kim VN (2020) Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing. Nature Structural & Molecular Biology. 27(6):581–588
(*co-first authors)

•    Jung S-J*, Choi Y*, Lee D, Roe J-H (2019) Nuclear aconitase antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA. Biochemical and Biophysical Research Communications. 516(3):806–811 (*co-first authors)

•    Jung S-J, Seo Y, Lee KC, Lee D, Roe J-H (2015) Essential function of Aco2, a fusion protein of aconitase and mitochondrial ribosomal protein bL21, in mitochondrial translation in fission yeast. FEBS Letters. 589(7):822–8 (selected as a critical research in the journal)

특허발표

•    Viral RNA Elements for Enhancing Expression and Stability of mRNA Containing Modified Nucleotides. Application No.1020260029813 Feb 2026.

•    Regulatory elements for enhancing RNA stability of mRNA translation and constructs containing the same. Application No.1020250009727 Jan 2026.

•    Novel regulatory elements for increasing gene expression, screening methods thereof, and uses. Application No. 1020250114491 Aug 2025.

•    New regulatory elements for enhancing RNA stability of mRNA translation and uses thereof. Application No. 1020250114472 Aug 2025.

•    New regulatory elements for enhancing RNA stability of mRNA translation and uses thereof. Application No. 1020250114471 Aug 2025.

•    Method for inhibiting infection and activation of virus. Application No. 2025-015295. Jan 2025. (Japan)

•    Novel regulatory element for enhancing RNA stability or mRNA translation, ZCCHC2 interacting therewith, and use thereof. Application No. 23831933.9. Jan 2025. (Europe)

•    Method for screening regulatory element for increasing mRNA translation, novel regulatory element resulting from method, and use thereof. Application No. 23831932.1 Jan 2025. (Europe)

•    Viral RNA element K4 enhancing gene expression and fragment sequences thereof. Application No. 1020250009727 Jan 2025.

•    Regulatory elements for improving mRNAs with modified bases. Application No. 1020250009733 Jan 2025.

•    Novel regulatory element for enhancing RNA stability or mRNA translation, ZCCHC2 interacting therewith, and use thereof. Application No. 2023301459. Jan 2025. (Australia)

•    Novel regulatory element for enhancing RNA stability or mRNA translation, ZCCHC2 interacting therewith, and use thereof. Application No. 19/003,919. Dec 2024. (United States)

•    Novel regulatory element for enhancing RNA stability or mRNA translation, ZCCHC2 interacting therewith, and use thereof. Application No. 2023800507437. Dec 2024. (China)

•    Method for screening regulatory element for increasing mRNA translation, novel regulatory element resulting from method, and use thereof. Application No. 19/003,992 Dec 2024.(United States)

•    Novel regulatory element for enhancing RNA stability or mRNA translation, ZCCHC2 interacting therewith, and use thereof. Application No. 2024-576351. Dec 2024. (Japan)

•    Regulatory elements for improving mRNAs with modified bases. Application No. 1020240110000 Aug 2024.

•    Method for inhibiting infection and activation of virus. JP Patent No. 07545148. Aug 2024. (Japan)

•    Method for inhibiting infection and activation of virus. JP Patent No. 07403777. Dec 2023. (Japan)

•    A method of screening elements that regulate cellular localization of RNA and new regulatory elements according to the method. Application No. 1020230086536. July 2023.

•    A method of screening regulatory elements for enhancing RNA stability or mRNA translation, new regulatory elements according to the method, and use thereof. Application No. 1020230084276. Jun 2023.

•    A method of screening regulatory elements for enhancing mRNA translation, new regulatory elements according to the method, and use thereof. Application No. 1020230084275. Jun 2023.

•    New regulatory elements for enhancing RNA stability or mRNA translation, ZCCHC2 interacting with the same, and use thereof. Application No. 1020230084274. Jun 2023.

•    Method for inhibiting infection and activation of virus. Application No. 2023-021944. Feb 2023. (Japan)

•    Viral elements identified by massively parallel screens. Application No. 11020220080073. Jun 2022.

•    Method for inhibiting infection and activation of virus. Application No. 62022050178.2. Mar 2022. (Hong Kong)

•    Method for inhibiting infection and activation of virus. Application No. 17/614,795. Nov 2021. (United States)

•    Method for inhibiting infection and activation of virus. Application No. 20813525.1. Nov 2021. (Europe)

•    Method for inhibiting infection and activation of virus. Application No. 202080039725.5. Nov 2021. (China)

•    Method for inhibiting infection and activation of virus. Patent No. 1020200066124. Jun 2020.

•    Regulation of Gene with TENT4A/B and RNA Stem Loop Structure. Patent No. 1020190064129. May 2020.